An Optimization via Simulation approach for the preemptive and non-preemptive multi-mode resource-constrained project scheduling problems

In this paper a novel modelling and solving method has been developed to address the so-called resource constrained project scheduling problem (RCPSP) where project tasks have multiple modes and also the preemption of activities are allowed.To solve this NP-hard problem, a new general optimization via simulation (OvS) approach has been developed wh

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Genetic Polymorphisms in Endothelin-1 as Predictors for Long-Term Survival and the Cardiac Index in Patients Undergoing On-Pump Cardiac Surgery.

Genetic variants within the endothelin-1 gene (EDN1) Used Catchers have been associated with several cardiovascular diseases and may act as genetic prognostic markers.Here, we explored the overall relevance of EDN1 polymorphisms for long-term survival in patients undergoing on-pump cardiac surgery.A prospectively collected cohort of 455 Caucasian p

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